Santiago
aging fisherman in Ernest Hemingway's "The Old Man and the Sea"
Santiago Fisterra
character in telenovela "La Reina del Sur"
Santiago
main character in The Alchemist by Paulo Coelho
Santiago
character in Anne Rice's "Interview with the Vampire"
Santiago
protagonist and troubled Jesus figure in the novella "Chronicle of a Death Foretold" by Gabriel García Márquez
Santiago
a character in "Santiago: a Myth of the Far Future" by Mike Resnick
Santiago
a character on TV's "Friday Night Lights"
Santiago Rivera
character in The Cluefinders game series
Hale Santiago
character in the Canadian television series "Lost Girl"
Amy Santiago
character on TV's "Brooklyn Nine,Nine"
Santiago "Jaime" Mendoza
Character in "Aristotle and Dante Discover the Secrets of the Universe", by Benjamin Alire Sáenz